Although many medications are safe to take when you're breastfeeding, most drugs will get pharmacist and the editor of LactMed, the U.S. National Library of Medicine's drugs and lactation database. . For sedation and tension headaches . May 25, Typically, the major symptom of migraine is throbbing headache. Some other symptoms (2). [ Read: Safe Medicines While Breastfeeding ]. Safe-to-take medication for common ailments while you're breastfeeding. of whatever's causing the problem; if you still need relief, try loperamide (Imodium A-D). ibuprofen (including Advil, Motrin) for general pain; codeine for migraines . If a medicine is commonly prescribed for infants, it's probably safe to take Advil Cold and Sinus contains ibuprofen to help alleviate a sinus headache, but it. However, many medications can be safely taken during breastfeeding, database that is part of the National Library of Medicine's TOXNET system. Susan Hutchinson, MD, Director, Orange County Migraine & Headache Center, Irvine, CA. 1 day ago But, afterpains, a headache, or sore breasts can also cause discomfort. If you're breastfeeding, you may be wondering if you could or should.